Mechanism of Action
Resalis is applying the cutting-edge LNA (locked nucleic acid) technology to inhibit miR-22 activity and restore a healthy homeostat in livers affected by metabolic disorders. miR-22 is a key player in the regulation of lipid metabolism and its levels are correlated with several metabolic disfunction including NAFLD (MAFLD) and obesity. Pharmacological inhibition of miR-22 proved able to protect mice from MAFLD and obesity, and to revert hepatic steatosis and fat accumulation in obese animals, paving the way for the development of anti-MAFLD therapy for humans.
Metabolic syndromes are very complex diseases regulated via multiple pathways, including several miR-22 target genes. Mechanistically, miR-22 orchestrates multiple pro-lipogenic programs modulating both direct and indirect targets. Inhibition of miR-22 via ASO LNA helps restoring regulation of lipid biosynthesis and promotes metabolic rewiring towards higher energy expenditure and browning of white adipose tissue, showing in parallel also a positive effect on prevention of fibrosis and inflammation.
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